Pelviora
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Pelviora

149,90 €

Pelviora® is a dietary supplement containing ingredients that boost the immune system, protect cells from oxidative stress, exert anti-inflammatory effects, reduce cortisol and anxiety, and improve sleep.

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Pelviora®

What is Pelviora® (120 capsules)?

Pelviora® is a dietary supplement that combines active ingredients with scientifically documented benefits, targeting specific areas.

The formulation of Pelviora® was inspired by published clinical studies documenting the reported beneficial (nutritional) effects of its selected ingredients—whether used individually or in combination—across various study groups. It was also specifically developed to address the nutritional needs of women suffering from conditions causing pelvic pain (endometriosis, adenomyosis, dysmenorrhea, dyspareunia, menopause) or of men and women with inflammatory joint conditions.

Its intended nutritional purpose is (in summary):

«Supporting the normal function of the immune system and supplementing the standard diet with antioxidants»

*For comprehensive information, you may wish to visit the scientific evidence section for Pelviora.

What is Pelviora® (120 caps) not?

Pelviora® is not a medicine

What is the packaging of Pelviora®?

Box with 120 capsules (8 x 15)

Why 120 capsules and not fewer?

Based on the recommended dosage and the available literature, the benefits of this nutritional regimen become measurably apparent after 3–6 months.

Why capsules and not another form?

Capsules were chosen to preserve the physicochemical characteristics of the ingredients and to ensure targeted daily intake and ease of administration (both practically and in terms of sensory experience).

Who can take Pelviora® and who cannot?

  • Pelviora® may be taken to support normal immune system function and to supplement the diet with antioxidants, or as directed by healthcare professionals (based on the expected benefit assessed by the healthcare professional).
  • It was designed with the specific nutritional needs in mind of women suffering from conditions causing pelvic pain (endometriosis, adenomyosis, dysmenorrhea, dyspareunia, menopause) or inflammatory joint conditions (regardless of gender).
  • Regarding exclusions for the use/consumption of Pelviora®, please consult the section “Warnings regarding Pelviora intake.”
  • In any case, it is recommended that you consult your doctor if you are currently on medication or have specific health issues.

What is the composition of Pelviora®?

Pycnogenol® (Horphag), EGCG (Camelia sinensis extract 98%), Ashwagandha (Withanolide Glycosides NLT 35%) / Shoden® (Withania Somnifera extract), Vitamin D3 (Cholocalsiferol), N-Acetyl cysteine, Selenium (Sodium Selenate), Zinc (Zinc Sulfate), Magnesium (Magnesium Biglycinate), Magnesium (stearate), HPMC Other ingredients: Hard vegetable capsule, Magnesium stearate

Active ingredientsDaily dose per capsule%RDA
1. Pycnogenol® (Horphag)30 mg-
2. EGCG97,3 mg-
3. Shoden® (Ashwagandha)60 mg-
4. N-Acetyl cysteine100 mg-
5. Vitamin D3400 IU66,66%
6. Selenium65 μg119,17%
7. Zinc9,23 mg92,3%
8. Magnesium (bisglycinate)65 mg17%
9. Magnesium (stearate)10 mg2,62%
10. HPMC125 mg-

*%RDA: % Recommended daily allowance

Dosage and duration of Pelviora® intake

  • Two (2) capsules daily with a full stomach, for at least 3–6 months
  • The attending physician may tailor the dosage. However, it is recommended not to exceed four (4) capsules per day.

Warnings regarding the use of Pelviora®

  • Do not exceed the recommended daily dose (Consult a healthcare professional!)
  • Do not consume simultaneously or concurrently (on the same day) with other products containing green tea
  • Do not consume a daily amount of EGCG equal to or greater than 800 mg
  • Not to be consumed by pregnant or lactating women and by children under 18 years of age
  • Do not consume on an empty stomach
  • As a dietary supplement, it should not be used as a substitute for a balanced diet
  • Not intended for the prevention, treatment or cure of human disease
  • Gluten free
  • Lactose free
  • Sugar-free
  • Consult your doctor if you are on medication or have health problems
  • Keep in a dry and cool place
  • Keep out of reach of small children
  • (Hellenic) Poisoning Care Line Telephone: +30 210 7793777

Is Pelviora® licensed by the EOF (National Drug Organization of Greece) ?

As a dietary supplement, Pelviora® is not subject to a licensing process.

However, it has been notified to the EOF (National Organization for Medicines), with EOF Notification No
115524/23-9-2026

Who is the marketing authorization holder for Pelviora®?

YK Medica P.C.

Ippodameias Square 8, Piraeus, 18531, Attica
Phone. +30 210 220 1039
www.ykmedica.gr | info@ykmedica.gr

Barcode: 5 214003 351020

Inspiration & Methodology

From the literature … to Pelviora®

Pelvis and Joints (sharing Inflammation and Pain as common factors)

Nutritional needs, potential deficiencies, and supportive approach

  • Endometriosis
  • Adenomyosis
  • Dysmenorrhea
  • Dyspareunia
  • Menopause
  • Inflammatory arthritis

Summary

  • Pathological conditions & symptom mechanisms.
  • Need for targeted nutritional management andcommon potential nutritional gaps
  • Pain, bleeding, gastrointestinal symptoms, and adverse drug reactions in relation to nutrition
  • Nutrition (which does not replace medical treatment) acts as a complement—within a holistic management framework or as an alternative approach employed by specialists—to address therapeutic gaps

Endometriosis

  • Chronic, estrogen-dependent inflammatory disease characterized by the presence of endometrial-like tissue outside the uterus
  • Commonly presents with: pelvic pain, dysmenorrhea, pain during intercourse, bowel/bladder symptoms, and potential infertility.

Adenomyosis

  • Endometrial tissue grows within the myometrium
  • Often causes heavy/prolonged menstruation and severe pain
  • Iron loss and risk of iron deficiency/anemia; management of the bleeding and the disease by a gynecologist remains a priority.

Dysmenorrhea

  • Painful menstruation; most commonly due to increased prostaglandin activity in the primary form
  • May coexist with endometriosis, adenomyosis, or other gynecological conditions.

Dyspareunia

  • Pain before, during, or after sexual intercourse; can be superficial or deep
  • Potential causes: endometriosis, pelvic floor issues, dryness/hormonal changes, infections, and other gynecological or psychosocial causes

Menopause

  • The decline in ovarian hormones affects bones, muscle mass, lipids, and cardiometabolic risk, as well as symptoms such as hot flashes and sleep disturbances.

Inflammatory joint conditions

  • These include diseases such as rheumatoid arthritis, psoriatic arthritis, and other forms of inflammatory arthritis.

Potential nutritional gaps due to illness

  • Heavy menstruation → iron/anemia.
  • Pain, fatigue, or nausea → reduced energy and protein intake.
  • Gastrointestinal symptoms → food restriction and potential low intake of fiber/micronutrients.
  • Reduced mobility → loss of muscle mass and reduced bone loading.
  • Restrictive “anti-inflammatory” diets → risk of deficiencies if not properly planned.

Medications: points to consider

  • NSAIDs: frequently used for pain; may cause gastrointestinal discomfort and, in some individuals, renal or cardiovascular complications.
  • Corticosteroids: prolonged use can affect bones, glucose levels, and muscle mass → pay special attention to calcium/vitamin D and protein intake.
  • DMARDs/biological agents: diet does not replace disease-modifying therapy. Checking for interactions and laboratory monitoring are required where indicated.
  • Hormonal therapies for gynecological conditions: individualized assessment; do not arbitrarily add herbs or supplements.

Nutritional Management

Literature data highlighted the composition of a multi-ingredient formulation with a daily dosage regimen of 1×2 (total daily dose):

  1. Pycnogenol® (Horphag) (60 mg)
  2. EGCG (Camelia sinensis extract 98%) (200 mg)
  3. Shoden® Ashwagandha (Withania Somnifera extract) (120 mg),
  4. N-Acetyl cysteine (100 mg)
  5. Vitamin D3 (Cholecalciferol) (20 μg)
  6. Selenium (Sodium selenite) (60 μg)
  7. Zinc (Zinc sulfate) (16 mg)
  8. Magnesium (Magnesium bisglycinate) (130 mg)

Need for recommendation by a specialist

  • Polyphenols possess biological/antioxidant activity, with evidence supporting specific clinical outcomes that vary by disease.
  • Assessment required for:
    • Medication use,
    • Pregnancy/breastfeeding,
    • Pre-existing hepatic/renal dysfunction,
    • Total micronutrient intake
  • Practical assessment framework
    • Diagnosis, symptoms, medications, and intervention goal
    • Dietary history and screening for restrictions/low intake
    • Combined testing (if indicated): CBC, ferritin/iron, 25-OH vitamin D, B12/folate, and other tests based on clinical presentation.
    • Targeted nutritional intervention and reassessment of symptoms/biomarkers
    • Administration at the appropriate dosage and monitoring for interactions.

Conclusions

  • Conclusions
    • Pelvic pain and inflammatory arthritis require medical diagnosis and personalized treatment
  • Key gaps in symptom-focused management:
    • Bleeding
    • Reduced intake
    • Gastrointestinal symptoms
    • Immobility
    • Pain
    • Adverse drug reactions
    • Impaired quality of life
    • Impact on mental health

Nutritional management differs from, though it can be combined with, general nutrition

the latter primarily targets nutritional adequacy, the maintenance of muscle and bone health, and overall metabolic support

Important Note

The above information is for educational purposes only and does not constitute personalized medical advice or dietary management instructions.
Clinical decisions are the responsibility of qualified healthcare professionals, whose recommendations are updated in accordance with current guidelines (ESHRE, ACR/EULAR, NAMS/EMAS, and national guidelines) and the patient’s full medical history.

Pain in Chronic Inflammatory Conditions

Endometriosis • Adenomyosis • Dysmenorrhea • Dyspareunia • Menopause • Inflammatory arthritis

From symptom to overall impact on quality of life

Chronic pain is not merely a symptom

  • Pain can become a central factor affecting functionality, sleep, energy levels, and relationships.
  • Persistent symptoms can fuel a vicious cycle: pain → stress → sleep disturbance/fatigue → reduced resilience → increased burden.
  • Effective care requires simultaneously addressing the underlying condition, the pain itself, and the modifiable factors that exacerbate it.

Where the problem arises

  • Gynecological pain
    • Endometriosis: chronic pelvic pain, dysmenorrhea, and often dyspareunia.
    • Adenomyosis: painful menstruation and pelvic discomfort/burden.
    • Dysmenorrhea: pain can interfere with school, work, and daily activities.
    • Dyspareunia: pain during sexual intercourse affects relationships and psychological well-being.
  • Hormonal & rheumatological issues
    • Menopause: symptoms, sleep disturbances, and mood changes can coexist.
    • Inflammatory arthritis: pain, stiffness, fatigue, and functional limitations.
    • Common denominator: symptoms affect multiple aspects of life.

Endometriosis & adenomyosis: beyond the pelvic region

  • Pain can be cyclical and/or constant and is associated with fatigue, sleep disturbances, and activity limitations.
  • Persistent symptoms can lead to activity avoidance and a sense of losing control.
  • Dyspareunia places a strain on relationships and sexual well-being.
  • Clinical goal: not merely reducing pain intensity, but restoring functionality and quality of life.

Dysmenorrhea & dyspareunia: pain affects behavior

  • Physical impact

    • Limitation of daily activities.
    • Fatigue and sleep disturbances.
    • Avoidance of exercise or social activities during symptom peaks.
  • Psychosocial impact

    • Anxiety regarding the next flare-up or sexual intercourse.
    • Strain on intimacy and relationships.
    • Pain management can indirectly improve the overall experience of the condition.

Menopause: pain, sleep, stress, and well-being

  • Changes during the menopausal period may be accompanied by sleep disturbances, fatigue, and mood swings.
  • When sleep and stress are compromised, symptom tolerance and daily functioning may decline.
  • Supporting sleep quality and stress management is an important complementary goal.

Inflammatory arthritis: pain leads to functional limitations

  • Pain and stiffness can reduce physical activity and exacerbate fatigue.
  • The chronic burden can affect work, social participation, sleep, and psychological resilience.
  • Supportive management does not replace treatment for the inflammatory disease.
  • Clinically useful framework: addressing the underlying disease + strategies for pain, sleep, stress, and functionality.

Goal: breaking the cycle

Psychological factors are part of pain management.

  • Chronic pain and stress interact bidirectionally.
  • Increased psychological burden can make it difficult to cope with daily life and adopt self-care behaviors.
  • Sleep is a critical mediating factor: recovery and sleep quality affect physical, psychological, and social functioning.
  • Therefore, addressing stress and sleep can serve as a complementary component of the overall management strategy.

Conclusions

  • Chronic pain affects the whole person—not just the affected organ.
  • Stress, sleep, fatigue, and psychological burden are critical elements of overall management.

Key areas for targeted benefits

Antioxidant & Anti-inflammatory Protection

  • Strong antioxidant protection (EGCG, NAC, Selenium, Pycnogenol®, Mg)
  • Support for natural anti-inflammatory defense (EGCG, NAC, D3, Se, Zn, Pycnogenol®, Mg)
  • Support for endogenous glutathione synthesis—the body’s primary antioxidant (NAC)
  • Support for cellular protection against oxidative stress (Se, Zn, EGCG, Pycnogenol®)
  • Synergistic antioxidant action between fat-soluble and water-soluble antioxidants (Pycnogenol®, EGCG, Se)

Immune System

  • Support for normal immune function (D3, Se, Zn)
  • Support for normal immune function during and after intense physical exercise (Zn, D3)
  • Role in the normal process of cell division, crucial for the immune response (Zn)
  • Support for normal thyroid function (Se, Zn)

Cardiovascular & Circulatory System

  • Support for normal endothelial function (Pycnogenol®)
  • Support for normal vascular function and vasodilation (Pycnogenol®)
  • Support for healthy circulation and microcirculation (Pycnogenol®, EGCG, Mg)
  • Support for normal blood pressure (Pycnogenol®, Mg)
  • Support for a healthy lipid profile (Pycnogenol®, EGCG)
  • Support for normal LDL levels (Pycnogenol®)
  • Support for normal HDL levels (Pycnogenol®)
  • Support for normal triglyceride levels (Pycnogenol®)
  • Support for normal platelet function (Pycnogenol®)
  • Support for vascular wall health (Pycnogenol®)
  • Support for normal venous function and relief from the sensation of “heavy legs” (Pycnogenol®)
  • Support for normal heart function via electrolyte balance (Mg)

Skin & Beauty

  • Support for skin health and structure (Pycnogenol®, Zn, Se)
  • Support for collagen and hyaluronic acid synthesis (Pycnogenol®) — the presentation notes an increase in type I collagen and hyaluronic acid expression
  • Support for skin elasticity and firmness (Pycnogenol®)
  • Support for skin hydration and the skin barrier (Pycnogenol®) — the study presented reports +21% hydration and +25% elasticity
  • Support for smooth and even skin texture (Pycnogenol®)
  • Support for the skin’s natural protection against UV radiation (Pycnogenol®)
  • Support for protection against photoaging (Pycnogenol®)
  • Support for even skin tone and a healthy appearance (Pycnogenol®)
  • Support for normal skin pigmentation (Pycnogenol®)
  • Support for the appearance of smooth, healthy skin (Pycnogenol®)
  • Support regarding the appearance of cellulite and smooth skin texture (Pycnogenol®) — the presentation includes a 12-week, double-blind, placebo-controlled study
  • Support for normal skin healing and integrity (Zn)
  • Support for the maintenance of the skin microbiome and skin defense (Zn, Se)

Hair & Scalp

  • Support for hair density and health (Pycnogenol®) — the presentation reports a significant increase in hair density in a clinical study
  • Support for scalp health and microcirculation (Pycnogenol®)
  • Support for maintaining scalp moisture (Pycnogenol®)
  • Support for normal hair growth (Zn)
  • Support for the normal keratin structure of hair and nails (Zn)

Connective Tissue & Bones

  • Support for connective tissue health and collagen-elastin structure (Pycnogenol®)
  • Support for normal skin microcirculation and tissue oxygenation (Pycnogenol®)
  • Support for bone health (D3, Zn, Mg, EGCG)
  • Support for normal calcium and phosphorus absorption and utilization (D3)
  • Support for maintaining normal blood calcium levels (D3)

Joints & Mobility

  • Support for normal joint function through synergistic mechanisms of action (Pycnogenol®) — inhibition of the pro-inflammatory “master switch” NF-κB (-15.5%), reduction of COX enzymes (up to -80% for COX-2) and 5-LOX (up to -75%), and reduction of MMP enzymes (-25%) associated with tissue degradation
  • Documented in over 10 clinical studies and scientific publications for joint health (Pycnogenol®)
  • Support for comfort and functionality in osteoarthritis — 56% pain reduction in osteoarthritis patients (Pycnogenol®) — Belcaro et al. 2008 study
  • Support for a 43% reduction in knee arthritis pain compared to the control group, alongside reduced NSAID use (Pycnogenol®) — Farid et al. 2007 study, 150mg/day, N=35
  • Supports reduced use of painkillers/NSAIDs — 38% reduction in NSAID dosage in the Pycnogenol® group versus an increase in the control group (Pycnogenol®) — Cisar et al. study 2008, 150mg/day, N=100
  • Supports improved flexibility and reduced joint pain and stiffness in 156 patients with osteoarthritis (pain -55%, stiffness -53%, physical function +56%) (Pycnogenol®) — Belcaro et al. study 2008, 100mg/day, N=156
  • Supports improved mobility — increase in walking distance on treadmill test from 68m to 198m versus 65m→88m in the control group (Pycnogenol®)
  • Supports reduction of pain and stiffness associated with arthritis/myalgia during perimenopause (-44.2% at 1 month, -54.4% at 3 months) (Pycnogenol®) — Kohama et al. study 2013, 60mg/day, N=170
  • Support for comfort in hand osteoarthritis — pain reduction of up to 72% (morning/after work/evening); only 9% of participants required painkillers (vs. 40% in the control group) (Pycnogenol®) — Cesarone et al. study 2024, 150mg/day, N=79
  • Support for hand/grip strength in hand osteoarthritis — increase from 6.4kg to 22.0kg; superior to control group (13.0kg) and diclofenac (16.0kg) (Pycnogenol®)
  • Support for the reduction of joint inflammation markers — reduction in erythrocyte sedimentation rate (-56%) and C-reactive protein (CRP) (-79%); fewer joints showing localized heat (32% vs. 70% in the control group) (Pycnogenol®)
  • Documented bioavailability in joints — detection of Pycnogenol® bioactive metabolites (taxifolin, ferulic acid, and caffeic acid) in synovial fluid after 3 weeks of administration (Pycnogenol®) — Mülek et al. study 2017
  • Support for protecting cartilage against degradation — reduction in the gene expression of catabolic/inflammatory markers MMP-3 (-53%), MMP-13 (-66%), and IL-1β (-64%) in the cartilage of patients with osteoarthritis (Pycnogenol®) — study by Jessberger et al. 2017, 200mg/day, N=30
  • Support for the reduction of serum cartilage degradation markers — reduction of ADAMTS-5 by 31 ng/mL and MMP-13 by 2.62 pg/mL versus an increase in the control group (Pycnogenol®)

Women’s Health

  • Support for women’s health and menstrual comfort (Pycnogenol®, Mg)
  • Support for normal balance during perimenopause/menopause (Pycnogenol®)

Muscles & Nervous System

  • Support for normal muscle and nervous system function (Mg)
  • Support for normal neuromuscular transmission (Mg)
  • Support for the reduction of fatigue and exhaustion (Mg)
  • Support for normal psychological function and stress management (Mg)
  • Support for restful sleep and relaxation (Mg)

Metabolism & Energy

  • Support for normal DNA, RNA, and protein synthesis (Mg)
  • Support for vitamin D metabolism and utilization (D3, Mg)
  • Support for normal macronutrient metabolism (carbohydrates, fats, proteins) (Mg, Zn)
  • Support for normal gene… expression (Zn)
  • Support for normal vision through antioxidant protection of the retina (Zn)
  • Support for normal cognitive function (Zn, EGCG)

Respiratory System & Detoxification

  • Support for normal respiratory system function through the antioxidant action of glutathione (NAC)
  • Support for normal liver detoxification mechanisms (NAC, Se)

Stress, Sleep & Vitality

  • Support for the normal stress response by modulating HPA axis (hypothalamus-pituitary-adrenal) activity (Shoden® Ashwagandha)
  • Support for a 30% reduction in perceived stress (DASS scale) in healthy stressed adults (Shoden® Ashwagandha) — 2019 study, 240mg/day, 60 days, N=60
  • Support for a 41% reduction in anxiety (Hamilton HAM-A scale) in the same study (Shoden® Ashwagandha)
  • Support for a 23% reduction in cortisol in the same study, and a 59% (anxiety) / 66-67% (cortisol) reduction in a 60mg & 120mg dosage study (Shoden® Ashwagandha) — Mishra & Kumar study, 2024, N=60
  • Support …managing stress hyper-reactivity through the regulation of cortisol and DHEA-S (Shoden® Ashwagandha)
  • Support for sleep quality and restorative sleep — 73% increase on the Restorative Sleep Questionnaire (RSQ) versus 25–29% for placebo (Shoden® Ashwagandha) — 2020 study, 120mg/day, 6 weeks, N=150
  • Support for reducing sleep onset latency (SOL) and wake after sleep onset (WASO), and for improving total sleep time and sleep efficiency (Shoden® Ashwagandha)
  • Support for quality of life (physical, psychological, social relationships, environment — WHOQOL scale) through improved sleep (Shoden® Ashwagandha)
  • Support for normal testosterone levels in men — an increase of 11–14% in two independent studies, and a dose-dependent increase of 22% (60 mg) / 33% (120 mg) in a third study (Shoden® Ashwagandha)
  • Support for vitality and a general sense of energy in adults (Shoden® Ashwagandha)
  • Support for normal immune function — increase in immunoglobulins IgA (+8.3%), IgM (+9.1%), and IgG (+11.6%) after 60 days (Shoden® Ashwagandha) — *Journal of Clinical Medicine* study, 60 mg/day, N=24
  • Support for the modulation of immune cells and cytokines (CD45, CD3, CD8, CD19, NK, IFN-γ, IL-4) in the same study, with the greatest change observed in IL-4 (+137.1%) (Shoden® Ashwagandha)

Concerning Shoden® Ashwagandha

Standardized Withania somnifera extract with ≥35% withanolide glycosides (HPLC standardization — the highest on the market at presentation), which are described as the most active water-soluble molecules of the plant and are associated with superior bioavailability over WS-5%/WS-10% extracts. It is supported by a safety study in humans (480mg/90 days, well tolerated, no adverse effects) and animals (NOAEL 1000mg/kg), as well as 11 publications and 23 patents

Table. Key pillars of Pycnogenol® positioning

AxisComposition
Antioxidant & AntiinflammatoryEGCG + NAC + Se + Pycnogenol®
Cardiovascular & CirculationPycnogenol® + Mg
Skin & BeautyPycnogenol® + Zn + Se
Women's healthPycnogenol® + Mg
Joint & mobilityPycnogenol® — 11 publications, documented effects on pain, stiffness, mobility, and cartilage (knee/hand osteoarthritis, menopausal joint/muscle discomfort)
Stress, sleep & vitalityShoden® Ashwagandha — 11 publications / 23 patents, documented effects on stress/anxiety (DASS, HAM-A, cortisol), sleep quality (RSQ, WHOQOL), testosterone/vitality in men, and the immune system (immunoglobulins, TBNK, cytokines)

Important Note

The above reflects findings from presentations/studies (Pycnogenol®, Shoden® Ashwagandha) and known, documented properties of the other ingredients (EGCG, NAC, Se, Zn, Mg, D3). This does not imply that every statement automatically constitutes an approved health claim under Regulation (EC) No 1924/2006 and the EFSA register.

Presentations

Pycnogenol for endometriosis and pain in dysmenorrhea – Horphag

Pycnogenol Joint Health – Horphag

Pycnogenol – Cardiovascular Health – Horphag

Pycnogenol for Skin Care – Horphag

Ashwagandha – Shoden

Bibliographic documentation (representative) of the active ingredients in Pelviora® – in addition to Pycnogenol® & Shoden®

EGCG (Epigallocatechin 3-gallate)

«Epigallocatechin 3-gallate (EGCG) possesses various biological functions, including anti-cancer and anti-inflammatory properties. …This review focuses on anti-cancer, anti-oxidant, anti-inflammatory, anti-angiogenesis, and apoptotic eff …»

«Epigallocatechin-3-gallate (EGCG), an active compound of green tea and its role in diseases cure and prevention has been proven. Its role in diseases management can be attributed to its antioxidant and anti-inflammatory properties. The anti-cancer role of thi …»

«As the principal bioactive component of Camellia sinensis, EGCG is celebrated for its potent antioxidant, anti-inflammatory, cardioprotective, and antitumor properties … Given the growing prevalence of lifestyle-related diseases and the increasing interest …»

«Among these, catechins-particularly epigallocatechin gallate (EGCG)-play a key role in regulating cell signaling pathways associated with various chronic conditions, including cardiovascular diseases, neurodegenerative disorders, metabolic diseases, and cancer. This review…»

«In this study, we show that hUMSC-Exo and EGCG act synergistically to reduce oxidative stress and exert potent anti-inflammatory effects. By incorporating these agents into a …»

«Among these catechins, (-)-epigallocatechin-3-gallate (EGCG), the most abundant polyphenol in green tea, has emerged as a promising therapeutic agent due to its potent antioxidant and anti-inflammatory effects. …By elucidating EGCG’s mechanisms of ac …»

«EGCG possesses intrinsic biological activities such as antioxidant, anti-inflammatory, anticancer, and drug resistance-modulating effects. In addition, the polyphenolic structure of EGCG enables diverse molecular interactions, including hydrophobic int…»

«Epigallocatechin gallate (EGCG), the predominant polyphenol in green tea, exerts a spectrum of physiological activities, including antioxidant, anticancer, and anti-inflammatory effects… This review delineates the main molecular features of EGCG and …»

«EGCG has excellent antioxidant activity, anti-inflammatory, osteogenesis-promoting, and antibacterial properties, and has been widely studied in orthopedic diseases such as osteoporosis… To sum up, it reveals the excellent development potential of material…»

«As the main polyphenolic bioactive substance in green tea, epigallocatechin-3-gallate (EGCG) exerts anti-inflammatory and antioxidant effects. In this study, we explore the potential mechanism by which EGCG relieves experimental colitis by regulating …»

«Highlighting its anti-inflammatory, antioxidant, and neuroprotective effects, EGCG is posited as a promising alternative to conventional pain medications, which are often associated with significant side effects and dependency risks…»

«“(-)-Epigallocatechin-3-gallate (EGCG) is a natural phenolic substance found in foods and beverages (especially tea) that exhibits a broad spectrum of biological activities, including antioxidant, antimicrobial, anti-obesity, anti-inflammatory, and anti-cancer …»

«The repression of the NF-kappaB pathway suggests anti-inflammatory effects for the antioxidant compounds that may also represent an indirect role in angiogenesis inhibition. The green tea flavonoid EGCG does target inflammatory cells, mostly neutrophils, and …»

«Through cellular, animal, and human experiments, green tea and its major component, epigallocatechin-3-gallate (EGCG) have been demonstrated to have anti-inflammatory effects. Our previous findings have indicated that green tea and EGCG suppress the …»

NAC (N-Acetyl Cysteine) & Vitamin D3

«N-acetyl-cysteine (NAC) is a known anti-inflammatory and antioxidant agent. Currently …»

«N-acetylcysteine (NAC), a compound known for its cysteine and glutathione precursor properties, has been used in therapeutic applications for many years. …Most studies suggest that NAC, whether used on its own or in combination with other medications, has the potential …»

«Calcitriol (Cal) is the most active metabolite of vitamin D and has antioxidant and anti-inflammatory properties. The aim of this study …»

«All of the enzymes that metabolize vitamin D seem to require magnesium, which acts as a cofactor in the enzymatic reactions in the liver and kidneys. …It is therefore essential to ensure that the recommended amount of magnesium is consumed to obtain the optimal be …»

Se (Sodium Selenate), Zn (Zinc Sulfate), Mg (Magnesium Biglycinate)

«Magnesium is required for DNA and RNA synthesis, reproduction, and protein synthesis. Moreover, magnesium is essential for the regulation of muscular contraction, blood pressure, insulin metabolism, cardiac excitability, vasomotor tone, nerve transmission and neurom …»

«Selenium (Se) is an essential trace element with antioxidant, immunological, and anti-inflammatory properties, which are attributed to its presence in selenoproteins, as the 21st amino acid selenocysteine. …We now have a clearer understanding of the …»

«The analysis showed the mediating role of leptin in the effects of zinc. Co-supplementation of selenium and zinc may have a synergistic effect in reduction of oxidative and inflammatory markers. Regarding the effect of zinc on inflammatory …»

«Deficits in magnesium have significant role in the pathogenesis of migraine. Mg has been extensively used in migraine prophylaxis and treatment. This review summarizes the role of Mg in migraine pathogenesis and the potential utilizations of Mg in the prevent …»

«An elevated endogenous cortisol level due to the peripartum stress is one of the risk factors of postpartum bovine uterine infections. Selenium is a trace element that elicits anti-inflammation and antioxidation properties …»

«A growing amount of evidence suggests that magnesium deficiency may play an important role in several clinical conditions concerning women health such as premenstrual syndrome, dysmenorrhea, and postmenopausal symptoms. A number of studies highlighted a positive cor …»

«Magnesium plays an important role in many physiological functions. Habitually low intakes of magnesium and in general the deficiency of this micronutrient induce changes in biochemical pathways that can increase the risk of illness and, in particular, chronic …»

«In addition, magnesium treatment is reportedly able to alleviate fibromyalgia, dysmenorrhea, headaches, and acute migraine attacks. Although magnesium plays an evolving role in pain management, better understanding of the mechanism underlying …»

«The application of systemic opioid and regional analgesia techniques has facilitated a decrease in the occurrence and gravity of pain. Magnesium has an evolving role in pain management. Magnesium sulfate (MgSO4), the pharmacological form of magnesium. …»

«This review provides a concise overview of the cellular and clinical aspects of the role of zinc, an essential micronutrient, in human physiology and discusses zinc-related pathological states. …Treatment involves zinc supplementation via zinc…»

«Additionally, magnesium’s anti-inflammatory properties may contribute to the alleviation of depressive symptoms. In the context of migraine’s pathophysiology, magnesium plays a role in regulating cerebral vascular tone, modulating the trigeminovascular …»

«Because of magnesium’s many functions within the body, it plays a major role in disease prevention and overall health. …This review presents recent research in the areas of magnesium and chronic disease, with the goal of emphasizing magnesium’…»

«Bone growth retardation is a common finding in various conditions associated with dietary zinc deficiency. Bone zinc content has been shown to decrease in aging, skeletal unloading, and postmenopausal conditions, suggesting its role in bone disorder…»

«Adipose tissue is considered an endocrine organ that promotes excessive production of reactive oxygen species when in excess, thus contributing to lipid peroxidation. Magnesium deficiency contributes to the development of oxidative stress in obese individuals, as this mine …»

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